Gilbert’s syndrome is a common, mild liver disorder in which the liver doesn’t properly process bilirubin, a substance produced by the breakdown of red blood cells. It’s a genetic condition, often inherited in an autosomal recessive manner, meaning a person must inherit two copies of an abnormal gene for the disease to develop. However, many people with Gilbert’s syndrome don’t experience any symptoms and discover the condition only when they undergo blood tests for unrelated reasons. But this is not the whole story. Many people with GS have a wide range of symptoms.
This yellowish pigment is a byproduct of the normal breakdown of red blood cells. Usually, the liver processes bilirubin, which is then excreted through the bile into the intestinal tract. However, in Gilbert’s syndrome, this process is mildly impaired.
Gilbert’s syndrome results from a genetic mutation in the UGT1A1 gene, which encodes an enzyme crucial for converting bilirubin into a form that can be eliminated from the body. This condition is inherited in an autosomal recessive pattern, meaning both copies of the gene in each cell have mutations. However, the symptoms are often so mild that they go unnoticed.
Most individuals with Gilbert’s syndrome are asymptomatic. However, some may experience mild jaundice, particularly during times of illness, stress, fasting, or over-exercising. The diagnosis is typically made when tests for liver function reveal elevated bilirubin levels, but normal liver enzyme levels.
Gilbert’s syndrome is generally considered harmless. It doesn’t require treatment, nor does it lead to serious liver problems. In fact, some studies suggest that the elevated bilirubin levels in Gilbert’s syndrome may offer some protection against heart disease by acting as an antioxidant.
If symptoms such as jaundice occur or persist, it’s important to consult a healthcare professional. While these symptoms are typically benign in the context of Gilbert’s syndrome, they could also indicate other medical conditions.
Hello, I’m the owner of this website, and I developed Gilbert’s Syndrome (GS) in my early 20s. If you’re here, it’s likely you’re seeking more information about this condition and exploring ways to alleviate its symptoms. In most cases, doctors offer only general recommendations, as specific treatments for GS are typically not necessary. However, here I’m gathering the latest research in this field, along with some practical life hacks that can help improve your quality of life.
Welcome to the club!
Disclaimer: The content provided on this website is for educational purposes only and is not intended as medical advice. It is not intended to diagnose, treat, cure, or prevent any health condition or disease. Patients should always consult with their family doctor or other qualified healthcare professionals for personalized medical advice.